Therapeutic Potential of Soybean Proteins for IBD Symptoms Seen in Mice

Therapeutic Potential of Soybean Proteins for IBD Symptoms Seen in Mice
Results from a preclinical study at Penn State show that soybean proteins can reduce inflammation and protect the gut barrier in mouse models of inflammatory bowel disease (IBD). These results may support additional clinical studies on the therapeutic use of soy protein in the diet of IBD patients. The study, “Soy protein concentrate mitigates markers of colonic inflammation and loss of gut barrier function in vitro and in vivo,” was published in The Journal of Nutritional Biochemistry. Soybeans and their purified proteins have been widely explored and studied as anticancer therapeutics. Although some studies suggested that soy consumption could reduce the risk of colon cancer, researchers have not seen conclusive evidence on the use of purified soy components. Previous experimental studies have reported that soy proteins can have antioxidant and anti-inflammatory effects. Indeed, replacement of the diet proteins for soy proteins showed promise in reducing IBD symptoms in animal models. However, scientists were not certain how this worked. Researchers from Pennsylvania State University aimed to unravel the protective mechanisms of soybean protein concentrates (SPC) in both experimental cell lines and animal models of IBD. Making use of therapeutically relevant doses of SPC, the authors found that SPC did protect cultured human colon cells from oxidative and inflammatory damage, and even death. In addition, by replacing pro
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