Medicines Targeting Inflammatory Factor IL-1 May Help Combat IBD, Study Suggests

Medicines Targeting Inflammatory Factor IL-1 May Help Combat IBD, Study Suggests
Scientists have discovered a potent inflammatory factor called interleukin (IL)-1  that is released during necroptosis, a type of cell death by suicide often present in inflammatory bowel disease (IBD). The discovery suggests that available medicines targeting IL-1 and future medicines developed to target this molecule may succeed as a new kind of therapeutics for inflammatory diseases including IBD and psoriasis. The study “Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner,” appeared in the journal Proceedings of the National Academy of Sciences (PNAS). Necroptosis takes place when cells become infected with a pathogen. In this sense, it represents
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