Researchers Identify Bacterial Link Between Crohn’s Disease and Joint Pain

Researchers Identify Bacterial Link Between Crohn’s Disease and Joint Pain
An invasive type of Escherichia coli (E. coli) bacteria involved in gut inflammation in Crohn's disease (CD) promotes joint pain, researchers have found. This information may help identify CD patients more likely to develop extra-intestinal symptoms and guide therapy choices. The study “IgA-coated E. coli enriched in Crohn's disease spondyloarthritis promote TH17-dependent inflammation” was published in the journal Science Translational Medicine. Patients with Crohn's disease are burdened with abdominal pain and diarrhea, but also can exhibit extra-intestinal manifestations, such as peripheral spondyloarthritis (SpA). This condition affects both the spine and joints. However, the underlying mechanism explaining how intestinal inflammation leads to SpA has been unknown. Now, a team of researchers has discovered a link between the conditions. The scientists analyzed the bacteria present in fecal samples retrieved from IBD patients with or without peripheral SpA. The analysis was performed using antibodies, called immunoglobulin-A (IgA). These bind to bacteria present in the fecal samples. The researchers then used the IgA-coated bacterial species to identify them. They detected a selective enrichment in IgA-coated E. coli in patients with Crohn’s disease-associated SpA (Crohn’s disease-SpA), but not in Crohn’s disease alone. Researchers found that the E. coli bacteria isolated from CD-SpA patients were similar to the adherent-invasive E. coli (AIEC), an opportunistic pathogen that increases inc
Subscribe or to access all post and page content.

One comment

Leave a Comment

Your email address will not be published. Required fields are marked *