Gene Protects Gut Against Damage from Bacteria, Researchers Discover

Gene Protects Gut Against Damage from Bacteria, Researchers Discover
A gene called Gatm protects the gut against injury and inflammation caused by digestive-tract bacteria, according to a study using mice models. The researchers believe their discovery may help scientists understand the mechanisms that cause inflammatory bowel disease (IBD) in humans, and find new ways to treat it. The study, “Creatine maintains intestinal homeostasis and protects against colitis,” was published in the Proceedings of the National Academy of Sciences. IBD is a chronic disease with a high rate of relapse. The lining of the digestive tract must be healed to achieve long-term remission. The healing re-establishes the balance between the body’s response to disease-causing bacteria and the harmless bacteria that reside in the gut. Normally the intestines' walls contain mucus that protects them from injury. If the mucus layer is not functioning properly, bacteria pass through the intestinal walls, causing excessive inflammation. Researchers used genetic screening in IBD mice models to try to identify genetic alterations correlating with IBD symptoms. They identified 27 alterations that might be associated with IBD. A mutation in the Gatm gene triggered similar symptoms in people with IBD, including diarrhea, weight loss, and the death of cells lining the intestine. "The Gatm gene is needed for the synthesis of creatine, a substance made in the liver that travels to the [mucus] barrier cells and allows them to utilize energy in an efficient manner," Nobel Laureate Dr. Bruce Beutler, senior author of the study, said in a
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