Low Vitamin D Levels Linked to Increased Risk of UC Relapse Among Patients in Remission

Low Vitamin D Levels Linked to Increased Risk of UC Relapse Among Patients in Remission
Low vitamin D serum levels during periods of clinical remission increase the risk of relapse in patients with ulcerative colitis (UC), a new study shows. The results indicate that patients with UC should be closely monitored for levels of vitamin D, and support the need for supplements in maintenance therapy if necessary. The study, “Low Serum Vitamin D During Remission Increases Risk of Clinical Relapse in Patients With Ulcerative Colitis,” was published in the journal Clinical Gastroenterology and Hepatology. “We showed that vitamin D levels are associated with baseline endoscopic and histologic inflammation severity during clinical remission, and are associated independently with the longitudinal risk of clinical relapse,” John Gubatan, MD, and colleagues from the Department of Medicine, division of gastroenterology and hepatology at Beth Israel Deaconess and Harvard Medical School in Boston, wrote, according to a news release. “These results suggest that vitamin D status is linked not only to current disease severity, but also has an impact on future risk of clinical relapse,” he added. Ulcerative colitis (UC) and Crohn’s disease (CD) are inflammatory bowel diseases (IBDs) that are chronic disorders of the gastrointestinal tract, believed to result from a complex interplay between genetic, environmental, immune, and microbial factors. Vitamin D status has been implicated with disease severity, but the clinical significance of low vitamin D levels among UC patients in clinical remission has been unclear. Gubatan and colleagues conducted a prospective analysis of 70 patients with UC in clinical remission (those with a score of 2 or less on the Simple Clinical Colitis Activity Index). All patients were recruited after a surveillance
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