Seek Temporary Relief Medications for Crohn's disease don't work immediately, so you will need to find some interim help. Over-the-counter pain medications and ointments may help. Loperamide for diarrhea, Tylenol for pain, and soothing balms for anal soreness should help while you're waiting for your meds to kick in. However, some over-the-counter pain relievers may aggravate your condition, so confirm with your doctor beforehand what you can and can't take. Read our five tips to help you to better self-manage your IBD while in college.