Infant IBD Patients Found to Get Well at Rate Similar to Older Children

Infant IBD Patients Found to Get Well at Rate Similar to Older Children
A study of infants who developed inflammatory bowel disease (IBD) found that they recovered at a rate similar to patients who became ill later in childhood. IBD developing during a child's first year is rare — seen in less than 1% of cases. The patients sometimes have other genetic conditions that trigger gut inflammation, such as Wiskott-Aldrich syndrome or hyper-IgM syndrome. Research has shown that mutations in the immune cytokine interleukin 10 (IL-10) gene or its receptor are linked to severe gut inflammation in infants. But most infants with IBD have normal IL-10 signaling, suggesting that other factors are at play. For the study, "Variable outcome in infantile-onset inflammatory bowel disease in an Asian cohort," which was published in the World Journal of Gastroenterology, researchers at University Malaya Medical Center in Malaysia and the University of Hong Kong analyzed the medical records of all childhood IBD patients treated at the medical center between 1996 and 2014. Forty-eight children underwent extensive exams to exclude other causes of gut inflammation. Physicians diagnosed them as having Crohn’s disease, ulcerative colitis (UC) or IBD-unclassified (IBD-U). None of the infants had mutations in the IL-10 or the IL-10 receptor genes. Six of the children (13 percent) were di
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