Vitamin D May Influence Patients’ Response to Treatment, Risk of Remission

Vitamin D May Influence Patients’ Response to Treatment, Risk of Remission
Vitamin D levels may influence response to treatment with anti-TNFα medications in patients with inflammatory bowel disease (IBD), according to new research that also linked low vitamin D to reduced risk of IBD remission. The research paper, “Higher 25-hydroxyvitamin D Levels Are Associated With Greater Odds Of Remission With Anti-Tumour Necrosis Factor-A Medications Among Patients With Inflammatory Bowel Diseases,” was published in the journal Alimentary Pharmacology and Therapeutics. Previous studies have shown that vitamin D deficiency is associated with IBD disease activity and may prolong the duration of therapy with anti-TNFα (an inflammatory protein) medications among IBD patients. To understand whether levels of vitamin D also could influence remission, researchers analyzed the medical records of 173 IBD patients from the Brigham and Women’s Hospital IBD Center database. Patients included in the study had vitamin D levels drawn within six months prior, or two weeks after, initiation of anti-TNFα therapy (infliximab or adalimumab) and had IBD remission at three months. The team observed that 122 patients had normal vitamin D levels, whereas 51 had low levels when they started anti-TNFα therapy. Results indicated that vitamin D levels were associated with remission after three months of therapy. Patients with lower vitamin D levels had lower risk of remission at this period compared to the other group, regardless of age, gender, diagnosis, type of anti-TNFα therapy, and first or subsequent anti-TNFα treatment received. “These results show a significant association between v
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4 comments

    • Tim Bossie says:

      The study does not go into the levels, but a level of 20 nanograms/milliliter to 50 ng/mL is considered adequate. A level less than 12 ng/mL indicates vitamin D deficiency.

  1. mathix says:

    “Patients with lower vitamin D levels had lower risk of remission”
    Risk of remission or risk of relapse? This changes everything.

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