Inflammatory Protein MMP9 May Protect Against Bowel-disease-related Colorectal Cancer

Inflammatory Protein MMP9 May Protect Against Bowel-disease-related Colorectal Cancer
An inflammatory protein called MMP9 may protect against the development of a colorectal cancer associated with chronic inflammatory processes, such as inflammatory bowel disease (IBD), according to a study. The research, “Epithelial Derived-Matrix Metalloproteinase (MMP9) Exhibits A Novel Defensive Role Of Tumor Suppressor In Colitis Associated Cancer By Activating MMP9-Notch1-ARF-p53 Axis,” was published in the journal Oncotarget. Inflammatory processes protect the body against disease-causing pathogens or tissue damage. But when these processes become too active or unregulated, they can lead to several health conditions, such as cancer. IBD, including ulcerative colitis and Crohn's disease, is characterized by partial or total inflammation of the digestive tract. Those with the disease are at high risk of developing a colitis-associated cancer (CAC). The risk increases with inflammation duration and severity. MMPs are a group of proteins that work by cleaving to other proteins, regulating their activity and maintaining cell function, both inside and outside the cell. But when MMPs are too active or are at higher than normal levels, they can cause cell dysfunction, leading to several undesired consequences. Higher levels of certain MMPs help cancer cells grow and spread to other organs, for example. MMP9 levels may actually protect against cancer, however. While normal cells have very low amounts of MMP9, inflammation prompts the epithelial cells lining the colon and intestine to produce the protein.
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