A Single Gene Variant, Once an Evolutionary Edge, Now Seen to Promote Diseases Like IBD

A Single Gene Variant, Once an Evolutionary Edge, Now Seen to Promote Diseases Like IBD
An alteration in a single gene, the Fads1 gene, may determine the risk for certain diseases, including inflammatory syndromes like inflammatory bowel disease (IBD). The study tracing the gene in human evolution and its effects, “PATZ1 down-regulates FADS1 by binding to rs174557 and is opposed by SP1/SREBP1c,” was published in the journal Nucleic Acids Research. Two genes,

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2 comments

  1. Adrian says:

    Is it a gain or loss of function mutation? The article isint super clear. And does it increase/decrease metabolism of omega 6 and 3 equally or differently?

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