Severe Food Poisoning May Be a Cause of Crohn’s Disease

Severe Food Poisoning May Be a Cause of Crohn’s Disease
People who had a severe bout of food poisoning may be at risk of infection by a type of  E. coli bacteria and, possibly, the onset of Crohn’s disease, according to a study published in the journal PLOS Pathogens. The study, “Acute Infectious Gastroenteritis Potentiates A Crohn's Disease Pathobiont To Fuel Ongoing Inflammation In The Post-Infectious Period,” was conducted by Cherrie Small and her colleagues at the Michael G. DeGroote Institute for Infectious Disease Research. Food poisoning — caused by infection with such food-borne organisms as CampylobacterSalmonellaShigella and E. coli O157:H7 —  is a common, but sometimes life-threatening, problem for millions of people. Although certain cases are symptom-free, others can range from mild intestinal discomfort to severe dehydration and bloody diarrhea. or worse. Researchers used mice with Crohn's disease — a debilitating bowel disease characterized by the inflammation of the intestines — to understand how food-poisoning bacteria might promote its development. They observed that, in these mice, acute infectious gastroenteritis (inflammation of the gastrointestinal tract) caused by common food-poisoning bacteria contributed to the growth of adherent-invasive E. coli (AIEC), which is associated with Crohn's onset. The team also noticed that, even after the bacteria that caused the food poisoning were eliminated, increased levels of AEIC remained in the mice's intes
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