Entyvio’s Effect in IBD Continues After Years of Treatment

Entyvio’s Effect in IBD Continues After Years of Treatment
Takeda recently published interim data showing that Entyvio (vedolizumab) treatment continues to be beneficial for people with ulcerative colitis or Crohn’s disease, whether or not they were treated with TNF-blockers at an earlier date. The study, “Long-term Efficacy of Vedolizumab for Ulcerative Colitis,” published in the Journal of Crohn's and Colitis, also shows that patients who got better when Entyvio was dosed once every eight weeks also benefited from the treatment when the dosing was increased to once every four weeks. Entyvio is an antibody that blocks the actions of the molecule alpha4beta7 in the gut mucosa. Entyvio prevents certain immune cells from infiltrating gut tissues. The GEMINI LTS clinical trial (NCT00790933) is exploring long-term safety data of Entyvio use. It includes patients who have not been treated with the drug before and patients who completed or dropped out of the earlier studies, GEMINI I (NCT00783718) and GEMINI II (NCT00783692). The GEMINI LTS trial is ongoing. The published data was collected from May 22, 2009 through June 27, 2013. The trial included 845 patients with ulcerative colitis from whom researchers assessed the treatment's effectiveness. At the end of the period, 532 patients were continuing treatment. Among 136 patients who had been followed for 104 weeks, 88% were in remiss
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One comment

  1. Great paper!
    This medication has revolutionized the RX of IBD, as we continue to observe deep remission in patients with longstanding disease who have failed other therapies.
    Novel treatment with other agents to provide non toxic cost effective therapy is warranted.

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