Vitamin A Compound May Help to Protect People with IBD from Colon Cancer

Vitamin A Compound May Help to Protect People with IBD from Colon Cancer
Vitamin A may help protect against colon cancer that is due to chronic bowel inflammation, according to findings of a recent study with mice. In the study, "Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8+ T Cell-Mediated Immunity in Colorectal Cancer," published in the journal Immunity, researchers found that mice with colon cancer caused by inflammation had lower levels of retinoic acid, a compound made in the body from vitamin A. When these mice were treated with retinoic acid, tumor growth slowed. Colon cancer is the second leading cause of cancer-related deaths in the United States. There is a “clear link” in humans between inflammatory bowel conditions, such as ulcerative colitis, and the development of colon (also known as bowel) cancer, according to Professor Edgar Engleman of Stanford University School of Medicine, and the study's lead researcher. “Retinoic acid has been known for years to be involved in suppressing inflammation in the intestine,” Engleman said in a news report. “We wanted to connect the dots and learn whether and how retinoic acid levels directly affect cancer development.” Researchers investigated the levels of retinoic acid in mice with colon cancer that developed from bowel inflammation. The team also looked at tumor samples from patients with colon cancer, also derived from different forms of chronic bowel inflammation, including ulcerative colitis. The results showed a retinoic acid defic
Subscribe or to access all post and page content.

Leave a Comment

Your email address will not be published. Required fields are marked *