Morphic Raises $51.5M to Develop Next-Generation Integrin Therapies for IBD, Other Diseases

Morphic Raises $51.5M to Develop Next-Generation Integrin Therapies for IBD, Other Diseases
Morphic Therapeutic announced that it has raised $51.5 million through Series A financing to advance products and bring them into clinical testing. The Massachusetts-based company specializes in oral integrins. SR One and Pfizer Venture Investments led the round, with participation from other investors that included Omega Funds and AbbVie Ventures. The company was founded in 2015 on work from the lab of Tim Springer, a professor at Harvard Medical School and Boston Children’s Hospital, who initially discovered integrins in the 1980s — spawning the first generation of integrins. Currently there are six injectable integrin treatments approved for inflammatory bowel diseases (IBD), such as Crohn’s disease and ulcerative colitis, and also for plaque psoriasis, multiple sclerosis, acute coronary syndrome, and for complications of percutaneous coronary procedures. Morphic is leveraging fresh findings from Springer’s lab it thinks might lead to the development of small molecule integrin inhibitors, an effort others have found challenging. “This is a tremendously exciting time in drug development, when scientific understanding has advanced significantly, creating a clear path forward for effective targeting of the integrin family using rationally designed small molecules,” Praveen Tipirneni, president and chief executive officer of Morphic Therapeutic, said in a press release. Integrins are transmembrane receptors that work as bridges for cell-cell and cell-extracellular matrix (ECM) interactions. When triggered, integrins activate chemical pathways to the interi
Subscribe or to access all post and page content.

Leave a Comment

Your email address will not be published. Required fields are marked *