MAP Infection-Associated Crohn’s Disease: RedHill Biopharma Shows Drug Potential

MAP Infection-Associated Crohn’s Disease: RedHill Biopharma Shows Drug Potential
RedHill Biopharma announced the publication of a peer-review article demonstrating the potential efficacy of RHB-104 for the treatment of Mycobacterium avium subspecies paratuberculosis (MAP) infection-associated Crohn’s disease. The article was authored by researchers from the Burnett School of Biomedical Sciences at the University of Central Florida (UCF) College of Medicine and titled “RHB-104 triple antibiotics combination in culture is bactericidal and should be effective for treatment of Crohn's disease associated with Mycobacterium paratuberculosis.” The study was published in the journal Gut Pathogens. RHB-104 is a patented oral antibiotic combination therapy with strong properties at the intracellular, anti-mycobacterial and anti-inflammatory levels. RHB-104 was grounded on emerging evidence that supports the hypothesis that Crohn’s disease is caused by MAP infections in susceptible patients. The article describes a preclinical study designed to evaluate the efficacy of RHB-104 active components (antibiotics clarithromycin, clofazimine and rifabutin) against MAP strains isolated from Crohn’s patients’ blood, tissue and milk. The preclinical study’s results showed that the active components of RHB-104, individually or dually combined, were not as effective against all microorganisms as triple combinations at minimum inhibitory concentration levels. Based on the results, the research team concluded that lower concentrations of the triple active components combination in RHB-104 could provide a better synergy against MAP growth activity. Consequently, the authors recommend the administration of RHB-104 for long-term treatment of Crohn’s disease. "We are pleased with the important findings described in this article which pr
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