Shire to License Rights for Pfizer’s IBD Drug PF-00547659

Shire to License Rights for Pfizer’s IBD Drug PF-00547659
The biotechnology company Shire will license global rights from Pfizer for PF-00547659, a drug under development for patients with moderate-to-severe inflammatory bowel disease (IBD). IBD is a group of conditions characterized by inflammation in the digestive tract, estimated to affect more than 3.5 million people in the U.S., European Union, and Japan. Two major types of IBD are ulcerative colitis and Crohn's disease, which usually cause symptoms such as pain, weigh loss, fatigue, and diarrhea. Treatment for IBD often focuses on reducing inflammation and disease symptoms. Pfizer's PF-00547659 is a monoclonal antibody that targets the adhesion molecule MAdCAM-1, expressed in the endothelial cells from the gastrointestinal tract, as well the spleen, nasal tissue, bladder, lung, and uterus. Because MAdCAM-1 binds to proteins expressed on the surface of lymphocytes that cause inflammation, PF-00547659 is able to inhibit the translocation of this lymphocytes from the bloodstream to the intestine. Pfizer's PF-00547659 was evaluated in more than 700 patients in Phase 1 and Phase 2 clinical trials. TURANDOT and OPERA are two randomized, multicenter, double-blind, placebo-controlled studies that evaluated the safety and efficacy of PF-00547659 in ulcerative colitis and Crohn's disease patients, respectively. Particularly in ulcerative colitis patients who failed to respond at least one previous treatment, PF-00547659 increased the remission rates and mucosal healing at week 12, when compared to patients receiving placebo. In patients with moderate to severe Crohn's disease, PF-00547659 treatment showed an increased response, although not significant, compared to placebo. Pr
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One comment

  1. tom says:

    To the Ian C. Read and Pfizer company. CBS anchor woman Cindy Hsu recently got involved in dirty coraption with infamous CBS anchor Otis Livingston to rob Pfizer company employees bank accounts. Never trust Cindy Hsu and Otis Livingston they are big problem for business and need to be arrested!!!!!!!!!!!!!!!!!

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