Fecal Microbiota Transplant Induces Steroid-free Remission in Ulcerative Colitis Patients, Study Reports

Fecal Microbiota Transplant Induces Steroid-free Remission in Ulcerative Colitis Patients, Study Reports
A clinical study found that multi-donor fecal microbiota transplantation (FMT) successfully induced clinical and endoscopic remission in patients with resistant active ulcerative colitis (UC). Results from the placebo-controlled trial were presented at the recent 11th Congress of the European Crohn’s and Colitis Organisation (ECCO), held in Amsterdam, the Netherlands. The physiological balance of bacteria communities in the gut is essential to overall health and well-being, as the so-called “good” bacteria perform important physiological functions, such as the breakdown of food and nutrients, development of the immune system, and protection against disease-causing pathogenic bacteria. Microbiota imbalance has been shown to be involved in the pathogenesis of UC. FMT, a procedure in which fecal matter collected from a tested healthy donor is mixed with a saline or other solution and given to a patient, often by colonoscopy or enema, aims to replace the good bacteria that has been, through a variety of factors, killed or suppressed. Some studies have reported favorable effects of FMT in UC patients. Researchers studied 81 patients with active UC resistant to standard therapies, conducted at three centers in Australia. Patients were randomly assigned to FMT treatment or placebo colonoscopic infusion on day one, followed by FMT or placebo enemas five days per week for eight weeks. Samples for the FMTs were obtained from three to seven unrelated donors. The study’s primary endpoint was a combined steroid-free clinical and endoscopic re
Subscribe or to access all post and page content.