Ulcerative Colitis Disease Activity: Rectosigmoidoscopy Strongly Correlates With Colonoscopy Results

Ulcerative Colitis Disease Activity: Rectosigmoidoscopy Strongly Correlates With Colonoscopy Results
In a new study, researchers compared the efficacy of two techniques, rectosigmoidoscopy and colonoscopy, for the measurement of endoscopic healing in patients with ulcerative colitis, and found a strong correlation between both methods in assessing disease activity and mucosal healing. The research article, “Agreement Between Rectosigmoidoscopy and Colonoscopy Analyses of Disease Activity and Healing in Patients With Ulcerative Colitis,” was published in the journal Gastroenterology. The standard practice in ulcerative colitis clinical trials is to perform an endoscopy limited to the rectum and sigmoid colon, called a rectosigmoidoscopy, in order to track disease activity and mucosal healing, since it is largely thought that the most severe disease is limited to this part of the intestine. However, researchers believe this assumption may miss inflammation-related damage in other parts of the intestine. Researchers have now investigated if rectosigmoidoscopies are adequate techniques to accurately assess ulcerative colitis activity and damage in the more proximal colon. The scientists analyzed data from a Phase 2 clinical trial, the EUCALYPTUS trial on etrolizumab (Genentech), who had enrolled patients with moderate to severe ulcerative colitis who were previously unresponsive to standard therapy. Mayo Clinic endoscopic subscores (MCSe) and ulcerative colitis endoscopic in
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