Depression Symptoms in Pediatric IBD Can Be Predicted by Inflammatory Markers and Disease Activity

Depression Symptoms in Pediatric IBD Can Be Predicted by Inflammatory Markers and Disease Activity
Results from a study recently presented at the 2015 Advances in IBD Meeting showed that inflammatory markers and disease activity were predictors of anhedonia and somatic-affective symptoms in pediatric patients with inflammatory bowel disease (IBD). The presentation was titled "Inflammatory vs. Non-inflammatory Predictors of Specific Depressive Symptoms in a Large Pediatric Cohort With IBD" (abstract O-017). “Rates of depression across all pediatric IBD [patients] range from 12% to 25%, and previous work in our group showed that nearly 20% of depressed youth with IBD have a somatic symptom-predominant phenotype of depression,” said Anne Levine, a medical student from University of Pittsburgh School of Medicine, during her presentation according to a news release. “It’s important to know that mood or affect itself can be associated with illness, and this has led to considerable debate over whether somatic symptoms truly represent depression or are simply a manifestation of [IBD]. With that debate in mind, we aimed to better understand the role that inflammation plays in somatic depression in this population. How much of somatic depression is and is not due to inflammation, and is it the whole story?” Levine and her colleagues examined 550 patients with Crohn’s disease (51.8% males, and with a mean age of 14.4 years) from Boston Children’s Hospit
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