New Inflammatory Bowel Disease Research Reveals Biofilm Product as Possible New Therapy

New Inflammatory Bowel Disease Research Reveals Biofilm Product as Possible New Therapy
A new study conducted in the Department of Microbiology and Immunology at the Lewis Katz School of Medicine (LKSOM) revealed that the naturally produced protein curli has anti-inflammatory effects in mice models of inflammatory bowel disease (IBD). The research paper, entitled “Biofilm-associated bacterial amyloids dampen inflammation in the gut: oral treatment with curli fibres reduces the severity of hapten-induced colitis in mice”, was published in Biofilms and Microbiomes, a journal from the Nature Publishing Group. IBD is a chronic, potentially life-threatening disease caused by an exacerbated and inappropriate immune response, leading to the inflammation of the digestive tract. Most management therapies rely on immunosuppressive medication, which can lead to adverse side effects such as bacterial infection. In order to explore potential new therapeutics for IBD, researchers have been investigating the influence of a protein called curli in the gastrointestinal tract and its potential as an anti-inflammatory agent. Curli is an amyloid protein secreted by strains of the Enterobacteriaceae family that form the biofilm of bacteria lining the gut. Biofilms are aggregates of bacteria, held together by an extracellular matrix that lines the gastrointestinal tract and contributes to its health and equilibrium. In this context, curli reinforces this epithelial layer, avoiding its disruption, minimizing the risk of inflammation. Curli has been shown to interact with toll-like receptor (TLR) 2, a regulator of anti-inflammatory response in
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One comment

  1. Kim Buhler says:

    I filled out a request for the study but was not selected. My son has a loop olio stony because his Crohns was so bad. He’s on stalera having failed other treatments. My other son is in total remission from a similar diagnosis having left all drug therapies. I really feel the key is gut bacteria. I wish there was a way to get him to try Curli and not have his colon removed.

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