Review Explores Link Between IBD, Th17 Immune Cells and Probiotics as a Potential Therapeutic Strategy

Review Explores Link Between IBD, Th17 Immune Cells and Probiotics as a Potential Therapeutic Strategy
A review study recently published in the International Journal of Molecular Sciences focused on the role played by specific immune cells in inflammatory bowel diseases (IBD), and their potential use as therapeutic targets through probiotics. The study is entitled “Th17 Cells as Potential Probiotic Therapeutic Targets in Inflammatory Bowel Diseases” and was led by researchers at Dedan Kimathi University of Technology in Kenya and Taipei Medical University in Taiwan. IBD is a chronic inflammatory condition of the digestive tract that primarily comprises ulcerative colitis and Crohn’s disease. It is characterized by vomiting, abdominal pain, rectal bleeding, diarrhea, fatigue and weight loss. IBD pathogenesis is mainly caused by an abnormal immune response against antigens of the intestinal cells and natural microbiota. It has been reported that specific immune cells called T helper 17 (Th17) cells play a role in IBD pathogenesis, and that these cells could represent a potential therapeutic target for disease prevention and management. Th17 cells are known to produce interleukin-17 (IL-17), which has a pro-inflammatory role. Probiotics are live bacteria and yeasts that provide a health benefit when ingested orally in adequate levels. Probiotics help to maintain a healthy gut by modulating the intestinal microbiota or by stimulating the local immune system. The use of probiotics has been shown to be effective in the prevention and treatment of IBD. Interestingly, there is a growing body of evidence suggesting that probiotics selectively target
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One comment

  1. Eric Bakker ND says:

    I have been talking about the benefits of probiotics for over 20 years now. I guess the new trend these days is that everyone is talking about probiotics.


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