Stereomicroscopy 3-D Views Of Intestines Could Yield Clues To Treating Inflammatory Bowel Disease

Stereomicroscopy 3-D Views Of Intestines Could Yield Clues To Treating Inflammatory Bowel Disease
A technology with roots dating back to the 19th Century is showing potential to offer new advantages for modern-day medicine. In findings published this month in the journal Nature Communications, scientists at Case Western Reserve University School of Medicine in Cleveland, Ohio, describe how stereomicroscopy can provide physicians with a valuable diagnostic tool for assessing issues within the gastrointestinal tract. Originally used by 19th-century photographers to create the illusion of depth of field in their viewed images, stereomicroscopy since has evolved to become a staple of the film and videogame industries. Only recently has medicine been giving it another look, a factor that makes these findings particularly important. Using 3-D pattern stereomicroscopy with mouse models, School of Medicine researchers report being able to develop entire topographical views of the inside of the intestinal system, rather than just two-dimensional visuals of individual sections or of tissue or cell samples. Stereomicroscopy's more expansive and detailed imagery allows them to identify distinct patterns related both to health and disease within those structures -- patterns they could not see using traditional approaches. The Nature Communications paper, entitled Stereomicroscopic 3D-pattern profiling of murine and human intestinal inflammation reveals unique structural phenotypes (Nature Communications 6, Article number: 7577 doi:10.1038/ncomms8577), is coauthored by Case Western Reserve professors Fabio Cominelli and Alex Rodriguez-Palacios, with Tomohiro Kodani, Lindsey Kaydo, Davide Pietropaoli, Daniele Corridoni, Jeffry Katz, and Theresa T. Pizarro, all of the Division of Gastroenterology and Liver Disease in Department of Medicine at Case Western Reserve Universit
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