Feijoa Inhibits TLR2-Induced Inflammation Suggesting a Role for Dietary Control in IBD Management

Feijoa Inhibits TLR2-Induced Inflammation Suggesting a Role for Dietary Control in IBD Management
In a new study entitled “Extracts of Feijoa Inhibit Toll-Like Receptor 2 Signaling and Activate Autophagy Implicating a Role in Dietary Control of IBD,” researchers investigated how a component extracted from a South American fruit, feijoa, was capable of reducing inflammation induced by a specific receptor of innate immunity, the Toll-like receptor 2, in intestinal epithelial cells. The study highlights the role of dietary components as a potential therapeutics in inflammatory bowel disease and was published in the journal PLOS One. Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the digestive tract that is notably populated by a community of commensal microorganisms referred to as microbiota, which is vital for a normal, healthy function of the gastrointestinal system. The immune system located within the intestine is a critical function for distinguishing between commensal microorganisms from those that are pathogenic. This is achieved via a series of receptors, such as pattern recognition receptors (PRRs) that recognize patterns in pathogenic microorganisms, pathogen-associated molecular patterns (PAMPs), and damage associated molecular patterns (DAMPs). One of the most important PPRs are Toll-like receptors (TLRs), which were shown to play a crucial role in the pathogenesis of IBD, a disease with limited treatment resources. In this study, the authors aimed to investigate how dietary intervention can help manage IBD symptoms and
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