Vitamin D Protects Against Inflammation in Crohn’s Disease, Helps Maintain Intestinal Permeability

Vitamin D Protects Against Inflammation in Crohn’s Disease, Helps Maintain Intestinal Permeability
In a new study entitled “Effects of vitamin D supplementation on intestinal permeability, cathelicidin and disease markers in Crohn’s disease: Results from a randomized double-blind placebo-controlled study,” researchers revealed how Vitamin D supplementation contributed to intestinal epithelia permeability and reduced inflammation in Crohn’s Disease patients. They found that patients on vitamin D supplementation have increased protection against inflammation and are capable of maintaining intestinal permeability. The study was published in the United European Gastroenterology journal. Crohn's disease (CD) is a type of inflammatory bowel disease (IBD), which is estimated to affect 1.6 million Americans. The second most common type of IBD is ulcerative colitis. CD is a long-term condition characterized by chronic inflammation occurring in any part of the gastrointestinal tract. It is established that a series of genetic and environmental cues contribute to CD development, however, recent studies with animal models as well as clinical data suggest that Vitamin D deficiency is a risk factor for CD. As a result, Vitamin D supplementation is a potential therapy for treating CD, as previous studies showed how vitamin D suppressed the development of IBD. However, while these studies demonstrated the effect of vitamin D on inflammation, how it impacts the permeability of the intestinal wall remains unknown (the barrier function of the intestinal epithelia and its permeability are key features
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2 comments

  1. Ashley Pearson says:

    They say this, but most people with Crohn’s disease will already be taking a multivitamin which has Vitamin D included. I sure haven’t felt much better since starting my multivitamin, I don’t know about anyone else.

    Perhaps I need to get the Vitamin D from other sources instead.

  2. Pat says:

    Dear Ashley,
    It certainly can’t hurt to try vitamin D to help your IBD. I take 2,000 units a day, but my
    IBD is so variable, I ‘m not sure if it has made a difference. However, a blood test showed
    that I was Vitamin D deficient! A multi vitamin usually doesn’t have enough D!
    Hoping it helps!

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