Vitamin D Supplementation May Offer a Beneficial Effect for Crohn’s Disease Patients

Vitamin D Supplementation May Offer a Beneficial Effect for Crohn’s Disease Patients
An international team led by researchers at St. James’s Hospital in Dublin, Ireland, recently reported that vitamin D may have a beneficial impact on the intestinal barrier dysfunction associated with Crohn's disease. The study was published in the United European Gastroenterology Journal and is titled “Effects of vitamin D supplementation on intestinal permeability, cathelicidin and disease markers in Crohn’s disease: Results from a randomized double-blind placebo-controlled study.” Crohn’s disease is a lifelong chronic inflammatory condition of the digestive tract that can cause fever, fatigue, abdominal pain, diarrhea, malnutrition, and weight loss. The disorder can reduce the patient’s quality of life, and is estimated to affect 3 in every 1,000 people in North America and Europe. There is no current cure for Crohn’s disease and its exact cause is unknown, although genetic, immune and environmental factors are thought to play a role. It has been suggested that vitamin D supplements may be able to induce a prolonged remission in Crohn’s disease patients; however, its clinical efficacy and mechanism of action remain poorly explained. In the study, researchers evaluated the changes in intestinal permeability, antimicrobial peptide concentrations, and disease biomarkers in Crohn’s disease patients in response to vitamin D supplementation. An increase in intestinal permeability is considered a measure of gut leakiness, which has been shown to be a predictor of clinical rel
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