Intestinal Inflammation May Underlie Vitamin D Deficiency in IBD Patients

Intestinal Inflammation May Underlie Vitamin D Deficiency in IBD Patients
In a new study entitled “The non dietary determinants of vitamin D status in pediatric inflammatory bowel disease,” authors investigated which mechanisms underlie the vitamin D deficiency commonly diagnosed among patients with inflammatory bowel disease (IBD). The study was published in the journal Nutrition. In this study, researchers investigated the mechanisms behind vitamin D deficiency in patients with inflammatory bowel disease (IBD). Previous results suggested that serum albumin (this parameter is a marker for protein-losing enteropathy, a condition characterized by severe loss of serum proteins into the intestine, and liver function) was the main contributor to vitamin D deficiency in IBD patients. To determine the underlying mechanisms for the lack of vitamin D and test the suggested hypothesis, researchers performed a retrospective study with 59 pediatric patients with IBD and with 116 healthy controls. The authors focused on a crucial step in vitamin D metabolism, the generation of an important intermediate, the (25[OH]D), and whether impairing this step leads to vitamin D deficiency. The team found that pediatric patients with IBD had a higher prevalence of vitamin D deficiency, specifically, 42.4% versus 26.7%, respectively. Additionally, IBD patients exhibited higher levels of alanine transaminase (ALT), a specific biomarker of liver damage. However, the team found no association between vitamin D and markers of hepatic inflammation in IBD patients. Notably, authors foun
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