Critical MicroRNA Found To Contribute To The Inflammatory Phenotype in IBD

Critical MicroRNA Found To Contribute To The Inflammatory Phenotype in IBD
Researchers at the University of Padova in Italy discovered that a high expression of a small RNA molecule known as microRNA-155 leads to the inflammatory phenotype typically seen in patients with inflammatory bowel disease (IBD). The study was published in the journal Experimental & Molecular Medicine and is entitled “MiR-155 modulates the inflammatory phenotype of intestinal myofibroblasts by targeting SOCS1 in ulcerative colitis.” IBD is a chronic, idiopathic inflammatory condition of the digestive tract that primarily comprises ulcerative colitis and Crohn’s disease. Patients with IBD can experience abdominal pain, vomiting, rectal bleeding, diarrhea, internal cramps in the pelvis region, fatigue and weight loss. It is unclear what triggers IBD, but the disorder is known to be associated with an immunological deregulation. Evidence has suggested that intestinal myofibroblast (IMF) cells are involved in the inflammation process seen in the intestinal mucosa. In IBD patients, IMFs suffer a phenotype alteration that leads to tissue destruction, activation of immune cells and mucosal damage. Patients with IBD have also been reported to have abnormal levels of the microRNA (miR)-155. MicroRNAs are small non-coding RNA molecules that play critical roles in the regulation of gene expression. The miR-155 is known to be involved in inflammation and immune responses, although its role in IBD physiopathology is poorly elucidated. In the study, researchers assessed
Subscribe or to access all post and page content.

Leave a Comment

Your email address will not be published. Required fields are marked *