Quality of Methods Reporting in Animal Models of Colitis Generally Deficient

Quality of Methods Reporting in Animal Models of Colitis Generally Deficient
Researchers at The University of Manchester in the U.K. say fixing deficiencies in method reporting of animal experiment results could save hundreds of thousands of pounds and stop commissioning of clinical trials that have no realistic hope of successful result. A research team led by Dr. Sheena Cruickshank of the UoM Faculty of Life Sciences, and Professor Andy Brass from the School of Computer Science analyzed 58 papers on research into inflammatory bowel disease published between 2000 and 2014. They discovered a wide variety in reporting methodology, and that vital data from experiments were missing, meaning that the studies couldn't be accurately reproduced in animal or human models, rendering them scientifically useless. The researchers found that in several instances, gender of the animal experimented on wasn't recorded -- a factor that can have significant bearing on results since female mice have stronger immune response than males. How the animals were housed will also impact on the results in experiments about the gut. Dr. Cruickshank notes that our immune systems are bombarded with potential infectious threats that they must recognize and respond to by killing or containing the threat. However, the immune system can be harmful too to us too when it isn't properly controlled, as is seen in allergies or autoimmune diseases like rheumatoid arthritis and Inflammatory Bowel Disease. Research at Dr. Cruickshank's lab focuses on how immune responses are initiated. Events that happen early in an immune response determine whether someone will be able to get ri
Subscribe or to access all post and page content.

Leave a Comment

Your email address will not be published. Required fields are marked *