International Research Team Seeking Crohn’s Disease Causes By Studying Family Factors

International Research Team Seeking Crohn’s Disease Causes By Studying Family Factors
A team of scientists at the University of Edinburgh are participating in a Canadian coordinated global quest to find causal mechanisms at work in development of the currently of an incurable bowel disorder Crohn's disease. The Crohn's and Colitis Canada Inflammatory Bowel Disease Genetics, Environmental, Microbial (GEM) Project, based at Mount Sinai Hospital in Toronto, Ontario, is an international research study attempting to determine possible causes for Crohn’s Disease by following healthy individuals who are at a higher risk for developing the disease over time. The researchers encourage healthy individuals who have a sibling and/or parent with Crohn’s Disease to join the effort and help find a cause. It is hoped that greater understanding of how takes hold can also help explain why the incidence of the disease is increasing alarmingly in certain global regions, including Scotland, and that that the research project's findings provide guidance for scientists in their effort to design better Crohn's treatments. The researchers say greater understanding of the workings of Crohn's could enable them to provide better health advice to families of persons afflicted. Crohn's disease is a devastating, incurable, chronic inflammatory bowel disease involving gastrointestinal tract inflammation that can occur anywhere along the convoluted pathway from mouth to anus. Crohn's symptoms typically include stomach pain, urgent diarrhea, rectal bleeding, weight loss, nausea, and profound lethargy that often lead to a lifetime of abdominal pain and sickness. It is believed that a variable concatenation of genetic, environmental and microbial factors is responsible for development of the disease although no precisely specific cause has been identified. There is curren
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