Study on Pathogenesis of Inflammatory Bowel Disease Reveals Promising Insights

Study on Pathogenesis of Inflammatory Bowel Disease Reveals Promising Insights
gut floraA new study on the role of Toll-like receptor 4 and the pathogenesis of inflammatory bowel disease (IBD) entitled “Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms: new data and a meta-analysis” was published in BMC Gastroenterology by Dr. Nezha Senhaji from the Laboratory of Genetic and Molecular Pathology (LGPM) at Hassan II University in Morocco. Inflammatory bowel disease is an idiopathic and chronic multifactorial disease of the gastrointestinal tract. It has been shown that IBD pathogenesis is associated with commensal bacterial flora and genes associated to the host immune system, but the precise mechanism is not clear. The research team evaluated if the TLR4 gene was associated with Crohn’s disease (CD) and ulcerative colitis (UC) within Moroccan patients, and evaluated its correlation with clinical manifestation of the disease. Single nucleotide polymorphisms in toll-like receptor 4 (TLR4) causes an unusual immune response to local intestinal flora that may induce the development of inflammatory bowel disease. The study enrolled 117 Moroccan patients, 83 with Crohn’s disease and 34 with ulcerative colitis, and 112 healthy unrelated blood donors. The diagnosis of CD or UC was determined based on standard clinic
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