Heart Attack, Stroke, Diabetes Could Be Avoided Through a Healthy Gut Microbiome

Heart Attack, Stroke, Diabetes Could Be Avoided Through a Healthy Gut Microbiome
gut microbiomeA new study entitled “Intestinal Epithelial Cell Toll-like Receptor 5 Regulates the Intestinal Microbiota to Prevent Low-Grade Inflammation and Metabolic Syndrome in Mice," suggests that maintaining a healthy gut microbiome, the population of microorganisms that populate the intestine, can prevent metabolic syndrome, thus reducing the risk of developing metabolic-associated syndromes, such as heart attacks, stroke, and diabetes. The study was published in the journal Gastroenterology. Metabolic syndrome is a condition where there is an imbalance of energy that is stored versus its utilization and is diagnosed in those who exhibit three out of the following five factors: abdominal obesity, high blood pressure, elevated fasting plasma glucose, high blood triglycerides, and low high-density cholesterol (HDL) levels. Here, the authors generated mice who lacked a key protein of the innate immune system – Toll-like receptor (TLR) 5 (TLR5) – but only in the intestinal epithelium and in a population of dendritic cells (CD11c+ cells). TLR5 is a receptor that recognizes a key component of bacteria, flagellin, and triggers an innate immune response. The authors a
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