Lipids Present in Modern Western Diet May Trigger Inflammation, Colon Cancer

Lipids Present in Modern Western Diet May Trigger Inflammation, Colon Cancer
inflammation and colon cancerA new study entitled “Sphingosine-1-phosphatelyase down regulation promotes coloncarcinogenesis through STAT3-activatedmicroRNAs” discovered that a class of lipids present in our diet — sphingolipids — can promote or protect colon cancer depending on their metabolic fate, according to the study now published in the online October issue of The Journal of Clinical Investigation. While a connection between inflammation and cancer has been long recognized, which players play a role in the transition from inflammation to carcinogenesis is still largely unknown. Patients with inflammatory bowel disease (IBD) are, in fact, a good example of this association, since they exhibit a higher incidence of colon cancer when compared to the general population. A potential underlying cause for the transition between inflammation to colon cancer might be found in industrialized countries' diet, since IBD and colon cancer are known to be higher in these countries. A team of researchers at the Children’s Hospital and Research Center Oakland (CHORI) tackled this point by studying colitis-associated cancer (CAC), an example of inflammation leading to carcinogenesis sequence. They studied bioactive sphingolipids, a class of lipids that are present in ou
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