New Crohn’s Disease Oral Antisense Therapy Data to Reveal Promising Results

New Crohn’s Disease Oral Antisense Therapy Data to Reveal Promising Results
Antisense therapyCelgene International Sàrl has announced that it will present at the United European Gastroenterology Week in Vienna, Austria, in the Section dedicated to New drugs for Inflammatory Bowel Disease. Celgene's presentation will focus on the results from a phase II clinical trial that evaluated an oral, topically active Smad7 antisense oligonucleotide, called Mongersen, in patients with active Crohn’s Disease. Inflammatory Bowel Disease (IBD) comprises a group of diseases characterized by chronic inflammation particularly of the colon and small intestine. The two main types of IBD are Crohn's disease (CD) and Ulcerative Colitis (UC). CD patients have an exacerbated response of their own immune system, triggered by a deficient activity of immunosuppressive cytokines, such as the transforming growth factor (TGF)-β1. The defective activity TGF-β1 is due to high levels of Smad7, an intracellular protein that by binding to TGF-β1 receptor prevents TGF-β1 activating signaling pathways. Mongersen (GED-0301) is an antisense oligonucleotide that decreases SMAD7 protein by targeting Smad7 messenger RNA (mRNA). The drug was designed to be released at the extremity of the small intestine (the terminal ileum) and near colon extremity (right colon), common areas affected in CD patients. The results that will be presented are from a double-blind, placebo-controlled trial that determined Mongersen's efficacy in steroid-dependent or steroid-resistant
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