Study Links IBD Factors To Increased Risk of Developing Colorectal Cancer

Study Links IBD Factors To Increased Risk of Developing Colorectal Cancer
Researchers continue to study the effect that inflammatory bowel disease has on increasing a patient's risk of developing colorectal cancer (CRC). Recently, IBD News Today's Dr. Ana De Barros reported on the results of an autophagy induction study in 40 unicellular parasitic species that is helping to identify novel therapeutic targets in patients suffering from colon cancer or inflammatory bowel disease (IBD). Now, a new study published in the August issue of Clinical Gastroenterology and Hepatology is outlining new data that suggests certain elevated proteins found in IBD patients contribute to a higher rate of colorectal cancer diagnoses. The study, entitled, "Serum Inflammatory Markers and Risk of Colorectal Cancer in Patients With Inflammatory Bowel Diseases," notes that the fact that IBD patients are at higher risk of developing colorectal cancer is not a new insight, as inflammation, which is directly associated with IBD, is now recognized as a major risk factor in the development of cancer. However, the methods used to correlate IBD and colorectal cancer diagnoses in the past have centered on the use of histologic severity -- no researcher has specifically sought to process data based on the prevalence of C-reactive protein (CRP) or the elevation of an erythrocyte sedimentation rate (ESR) in an IBD study group to see how colorectal cancer diagnoses relate to these factors. The design of the study, which was led by Ashwin N. Ananthakrishnanemail, an assistant professor of medicine at Massachusetts General Hospital, and also involved researchers Su–Chun Cheng, Tianxi Cai, Andrew Cagan, Vivian S. Gainer, Peter Szolovits, Stanley Y. Shaw, Susanne Churchill, Elizabeth W. Karlson, Shawn N. Murphy, Isaac Kohane, Katherine P. Liao, was to work with a
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