Autophagy Induction Study in Inflammatory Bowel Disease, Colon Cancer Leads to New Insights

Autophagy Induction Study in Inflammatory Bowel Disease, Colon Cancer Leads to New Insights
autophagy and IBDA team of international researchers has studied autophagy induction in 40 unicellular parasitic species that could help identify novel therapeutic targets in patients suffering from colon cancer or inflammatory bowel disease (IBD). Autophagy is a highly conserved lysosome-mediated self-degradation process, involved in survival during starvation in eukaryotic cells and also in several cellular processes, such as stress-response, protein metabolism, differentiation and aging. This is an important process that allows intracellular pathogenic clearance, and its malfunction can lead to IBD as well as cancer progression. Furthermore, autophagy is also important for life-cycle transitions in parasites such as Trypanosoma and Plasmodium, involved in sleeping sickness and malaria, respectively. Nevertheless, studies have yet to show how autophagy is induced in these parasites. In this study, entitled "Starvation-response may not involve Atg1-dependent autophagy induction in non-unikont parasites" and published in Nature's Scientific Reports, researchers used a bioinformatics approach, scanning the genomes of 40 unicellular protists parasites to examine the presence of Atg1/ULK1-like autophagy inducing complex, the primary complex inducing autophagy that receives signals of cellular n
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