Compound Used in Food Packaging Linked to Severe IBD Symptoms in Animal Study

Compound Used in Food Packaging Linked to Severe IBD Symptoms in Animal Study
Bisphenol-A, a compound used in the production of some plastics and resins that line containers of canned foods and beverages, was seen to worsen symptoms and increased mortality in a mouse model of ulcerative colitis, a type of inflammatory bowel disease (IBD), raising concerns about its potential effects on people. The compound, also known as BPA, was found to affect mice body weight, stool consistency and rectal bleeding, and to increase gut inflammation and mortality, researchers reported. Their study,  “Bisphenol-A alters microbiota metabolites derived from aromatic amino acids and worsens disease activity during colitis,” was published in the journal Experimental Biology and Medicine. Although the exact causes of the different forms of IBD, including ulcerative colitis and Crohn’s disease, are largely unknown, physicians and researchers have identified  a number of potential environmental risk factors. These include smoking, diet, infections, toxins and medications. Estrogen, a hormone responsible for the development and regulation of the female reproductive system, is also considered a risk factor for IBD. Bisphenol-A can act as estrogen in the body, but it effects on IBD were not yet discovered. Since humans are exposed to high levels of BPA through the use of plastic containers and the consumption of canned foods, researchers at Texas A&M University  studied the effect of the compound on the exacerbation of inflammation  in the colon (a part of the gut) and on the type of amino acids produced by the gu
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